Macrophages (MFs) are mononuclear phagocytes of the innate immune system. Macrophages include Kupffer cells in the liver, microglia in the brain, alveolar MFs in the lung etc. and have a wide variety of functions. Classically activated MFs (M1) have bactericidal, tumoricidal and inflammation inducing properties. Alternatively activated MFs (M2) are responsible for the resolution of inflammation, tissue remodelling and angiogenesis. MF dysfunction has been observed in various diseses such as chronic inflammation, atherosclerosis, tumor promotion and metastasis. Better understanding of MF polarization could lead to potential therapies in diseases where MF dysfunction occurs. Our research focuses on the role of PARP family in the signaling pathways of MF polarization (M1 and M2). Our aim is to characterize new mechanisms in MF signaling potentially leading to new therapeutic modalities.